When the Kansas City Chiefs play the Los Angeles Chargers at 8 p.m. ET on Friday, Sept. 5, our projection system predicts the Chiefs will come out on top. Our model also projects the spead, point total, and final score, which you can read below.
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Chiefs vs. Chargers Game Info and TV Channel
- When: Friday, September 5, 2025 at 8 p.m. ET
- Where: Corinthians Arena in São Paulo, Brazil
- TV: YouTube
- Live Stream: Watch this game on Fubo (Regional restrictions may apply)
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Listen to the game on ALT 98.7
Chiefs vs. Chargers Odds and Betting Info
- Spread favorite: Chiefs (-3)
- Moneyline: Chiefs (-168), Chargers (+143)
- Total: 47.5 points
Chiefs vs. Chargers Prediction
- Pick ATS: Chargers (+3)
- Pick OU: Under (47.5)
Prediction:
Chiefs 21 - Chargers 20
Prediction derived from a team strength comparison algorithm. Multiple factors such as strength of wins and scoring margin are used to make this projection.
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Chiefs vs. Chargers Betting Insights (2024 Stats)
- The Chiefs covered seven times in 17 games with a spread last season.
- The Chargers put together a 12-4-1 record against the spread last season.
- Kansas City was 5-7-1 ATS last season when playing as at least 3-point favorites.
- Los Angeles covered the spread once when an underdog by 3 points or more last year (in three opportunities).
- Last season, seven of the Chiefs' games hit the over.
- A total of eight Chargers games last year hit the over.
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