The USC Trojans (4-0) and the Illinois Fighting Illini (3-1) square off on Saturday, September 27, 2025 at Memorial Stadium (Champaign, IL) in a battle of Big Ten opponents.
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USC vs. Illinois Matchup Info
- Game date: Saturday, September 27, 2025
- Game time: 12 p.m. ET
- Location: Champaign, Illinois
- Venue: Memorial Stadium (Champaign, IL)
- TV channel: FOX
- Live Stream: Watch this game on Fubo (Regional restrictions may apply)
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USC vs. Illinois Odds and Prediction
- Spread favorite: Trojans (-6.5)
- Moneyline: Trojans (-248), Fighting Illini (+202)
- Total: 61 points
- Pick ATS: Illinois (+6.5)
- Pick OU: Over (61)
- Prediction: Illinois 38, USC 27
Prediction derived from a team strength comparison algorithm. Multiple factors such as strength of wins and scoring margin are used to make this projection.
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USC vs. Illinois Betting Records and Insights
- USC has won two games against the spread this season.
- Illinois has compiled a 3-1-0 record against the spread this year.
- The Trojans have covered the spread twice this season (2-2 ATS) when playing as at least 6.5-point favorites.
- The Fighting Illini have not covered the spread this season (0-1 ATS) when playing as at least 6.5-point underdogs.
- So far this season, three of USC's four games have gone over the point total.
- So far this season, two Illinois games have gone over the point total.